A drug company said Friday that a medicine it sells to tamp down inflammation has helped prevent the need for breathing machines in hospitalized COVID-19 patients in the first large study that primarily enrolled Hispanics and Blacks.
Switzerland-based Roche reported the results for tocilizumab, sold now as Actemra and RoActemra for treating rheumatoid arthritis and some other diseases. The company said it would quickly publish the results, which have not yet been reviewed by independent scientists, and would speak with regulators about next steps.
The drug, given through an IV, tamps down a protein called interleukin-6 that’s often found in excess in COVID-19 patients. It failed in a previous study that tested it in people more severely ill from the coronavirus. The new study was done in the United States, South Africa, Kenya, Brazil, Mexico and Peru. About 85% of the 389 participants were Hispanic, Black, Native American or other ethnic or racial minorities. These groups have been disproportionately hurt by the pandemic.
In other developments:
- Companies are struggling to recruit diverse volunteers in final U.S. tests of possible COVID-19 vaccines. Minority enrollment in studies of two shots has inched up in recent weeks, but even more is needed this fall as additional vaccine testing gets underway over the next two months.
- Europe’s largest security organization said Friday that it has drastically scaled back plans to send as many as 500 observers to the U.S. to monitor the Nov. 3 presidential election and now will deploy just 30 because of the coronavirus pandemic.
- U.S. health officials are dropping a controversial piece of coronavirus guidance and telling all those who have been in close contact with infected people to get tested.
- House Speaker Nancy Pelosi pushed back Friday against the Catholic archbishop of San Francisco's criticism of COVID-related restrictions, saying he should “follow science” rather than advocate for fuller in-person gatherings for Mass and worship.
- The dismissed captain of a U.S. Navy aircraft carrier knew he was jeopardizing his military career when he sent a now-famous email warning of possible sailor deaths due to a coronavirus breakout on board.
- The number of FBS college football games postponed or canceled because of COVID-19 issues since Aug. 26 is 16 and the pandemic's impact is being felt in other sports; one of college basketball's premier tournaments is moving from Hawaii to North Carolina and the NCAA delayed the start of the basketball season to Nov. 25.
- Fresh nationwide lockdown restrictions in England appear to be on the cards soon as the British government targeted more areas Friday in an attempt to suppress a sharp spike in new coronavirus infections.
- Many residents in Madrid will need a reason to leave their neighborhoods and will face limitations on group gatherings even stricter than the ones in place as authorities moved Friday to try to rein in Europe's fastest-spreading second coronavirus wave.
- Guatemalan President Alejandro Giammattei says he has tested positive for the new coronavirus. The announcement came on the same day that the country reopened its borders and international flights after a six-month closure due to the coronavirus pandemic.
For more summaries and full reports, please select from the articles below. Scroll further for some virus basics and the latest numbers.
How will office life be different in a pandemic?
The office you once knew is likely to look vastly different.
Companies are taking a variety of steps to keep people a safe distance apart, such as using staggered shifts or asking people to come in on alternating days. Cubicles may also have higher walls or there may be new partitions between desks for added protection.
Kitchens, conference rooms and other common areas may be closed, and some offices have implemented one-way paths to keep people from passing each other. For essential shared spaces like elevators and bathrooms, face coverings could be required and there may be more frequent cleanings and limits on how many people can enter at one time. That could mean longer waits to use them.
Even with such social distancing measures, expect to wear a mask, especially when you're not at your desk. Your company will also likely ask you to report if you are having any symptoms.
The U.S. Centers for Disease Control and Prevention offers guidelines on keeping offices safe. But the specific measures at your office will vary depending on the company and any local rules. In the latest phase of New York state's reopening plan, for example, office capacity is capped at 50%.
The pandemic may also prompt changes that aren't directly about safety. At Bergmeyer, a design firm in Boston, the lights were adjusted to make Zoom calls look better.
Can you get the coronavirus twice?
Health experts think people who had COVID-19 will have some immunity against a repeat infection. But they don't know how much protection or how long it would last.
There have been reports of people testing positive for the virus weeks after they were believed to have recovered, leading some to think they may have been reinfected. More likely, experts say people were suffering from the same illness or the tests detected remnants of the original infection. There's also the chance tests could have been false positives.
Scientists say there has been no documented instance of a patient spreading the virus to others after retesting positive.
With similar viruses, studies have shown that people could fall sick again three months to a year after their first infections. It's still too early to know whether that's also possible with the coronavirus.
"It's very much emerging science," said Dr. Philip Landrigan, director of the global public health program at Boston College.
A small U.S. study published last week also found the antibodies that fight the coronavirus may only last a few months in people with mild illness, suggesting people could become susceptible again. But antibodies aren't the only defense against a virus, and the other parts of the immune system could also help provide protection.
Settling the question of whether reinfection is possible is important. If it can occur, that could undermine the idea of "immunity passports" for returning back to workplaces. And it would not bode well for hopes of getting a long-lasting vaccine.
Why are coins hard to find during the pandemic?
The Federal Reserve has seen a significant decline of coins in circulation because people are not spending them as regularly at businesses, many of which are either temporarily closed or not accepting cash.
Coins are still plentiful. In April, the U.S. Treasury estimated more than $47.8 billion were in the market, up by more than a billion dollars compared to last year.
But in recent months, people have not been spending those coins at places like laundromats, banks, restaurants, or shops because the businesses are closed, or people are not visiting them as often as they were before the pandemic.
"The typical places where coin enters our society have slowed or even stopped the normal circulation of coin," said the Federal Reserve, which manages coin inventory, in a June statement.
Sales at restaurants, bars and gas stations dropped more than 40% in April compared with a year ago. Sales have since picked up, but some businesses — like bars — remain shuttered in certain states, while others can only operate at a limited capacity.
The Federal Reserve has encouraged banks to order only the coins they need and to make depositing coins easy for customers. One Wisconsin bank system offered its customers a $5 bonus for every $100 in coins they brought into exchange at a branch.
The program was so successful, the bank suspended it after only a week.
Is it safe to go to the gym during the coronavirus pandemic?
It depends on where you live and the precautions you and the gym take.
If cases of COVID-19 are poorly controlled where you live, experts say it's best to stay away. But if you live in an area where the spread is being contained, there are ways to minimize risk when going for a workout.
To ensure everyone stays at least 6 feet apart, gyms should take steps such as moving machines, blocking off areas and limiting the number of people allowed inside, says Dr. Marybeth Sexton, an assistant professor of infectious diseases at Emory University.
Avoiding the locker room, bringing your own water bottle and using hand sanitizer also helps reduce risk, Sexton says.
The U.S. Centers for Disease Control and Prevention also suggests checking in online, rather than in person, and seeking activities that are outdoors instead of indoors when possible.
Gym staff should be cleaning exercise machines between uses and regularly wiping down other frequently touched areas with products that kill viruses.
And experts say face coverings should be worn at the gym whenever possible.
Sexton also suggests bringing a backup mask. If the one you're wearing gets really damp with sweat, she says it might not be as effective.
Even for those being careful, gyms pose a risk. Many are indoors, where ventilation is limited and social distancing can be challenging. In an ongoing pandemic, if you can manage to break a sweat without returning to the gym just yet, that's the best option, according to Sexton.
"If you can exercise by yourself outside, that's safer than being at the gym," she said.
Is it safe to drink from a fountain during the pandemic?
Is it safe to drink from a water fountain during the pandemic?
There’s no evidence you can get COVID-19 from the water itself. But since the virus may linger on surfaces, experts say to avoid fountains if you can or to limit any direct contact when using them.
In New York City, for example, posters instruct people to use gloves or a tissue to turn on water fountains. If you don’t have those handy and need to touch the fountain, experts recommend you wash your hands afterward and avoid touching your face until you do. And you shouldn’t let your face touch the spout when leaning in for a drink.
Filling a water bottle is also better than drinking directly from the fountain, says Angela Rasmussen, a virus researcher at Columbia University. That helps ensure you don’t leave saliva on the fountain, making it safer for others.
The precautions are recommended because surfaces are believed to contribute to the spread of COVID-19, even though experts say the main way the virus spreads is through droplets people spray when they talk, cough or sneeze.
To minimize direct contact with fountains, schools and businesses should encourage everyone to bring their own water from home, says the U.S. Centers for Disease Control and Prevention. Fountains should still be cleaned and sanitized for those who need to use them, the agency says.
The CDC also says schools and businesses should check fountains for other safety issues before they reopen. Prolonged closures could increase the risk for Legionnaires’ and other diseases associated with water, since standing water in plumbing systems can cause bacteria to grow.
Is it safe to ride public transit during the pandemic?
Is it safe to ride public transit during the coronavirus pandemic?
It depends on a variety of factors, but there are ways to minimize risk.
The main way that the virus spreads is through droplets people spray when they talk, cough or sneeze. That means the best way to reduce the spread of infection on public transit and elsewhere is to wear and mask and stay 6 feet from others, experts say.
Transit systems around the world are requiring riders to wear masks and encouraging people to socially distance. Compliance could vary, especially as ridership levels start rebounding and trains and buses get more crowded. But there are other steps you can take to make trips less risky.
The U.S. Centers for Disease Control and Prevention suggests traveling during non-peak hours, avoiding crowded spots in stations and stops, and skipping rows between seats when possible.
Surfaces are also believed to pose a risk, though to a lesser degree, and transit systems are employing a variety of cleaning techniques. Moscow and Shanghai have experimented with germ-killing ultraviolet light and Hong Kong has deployed a robot that sprays hydrogen peroxide. In New York, subways are shut down overnight overnight for cleaning.
Even so, the CDC says to avoid touching surfaces such as turnstiles and handrails if you can.
Though much remains unknown about the virus and how it spreads, experts note there have not yet been any major outbreaks linked to transit systems.
Has the coronavirus mutated in any significant way?
Coronavirus doesn't seem to have changed in a way that makes people less or more sick. There's some evidence that a specific mutation called D614G may have made it easier for the virus to be transmitted between people. But not all scientists are convinced, and it's hard to say how strong any such effect might be.
The D614G mutation, which appeared quite early in the pandemic, has since become so common that most outbreaks are caused by strains that carry it.
It's normal for viruses to mutate over time, but most genetic changes don't affect their behavior.
Who does a facemask really protect? Me or others?
Does a face mask protect me, or just the people around me? It likely provides protection for both.
Studies on the new coronavirus and other germs show wearing a mask helps stop infected people from spreading disease to others. Evidence also suggests that masks may offer some protection for the people wearing them.
The virus spreads from droplets people spray when they cough, sneeze or talk. Surgical or cloth face masks can block most of those particles from spreading.
While some droplets may still spread out, wearing a mask could reduce the amount, providing a benefit to others. Research shows people don't get as sick when exposed to smaller amounts of virus, said Dr. Monica Gandhi, a virus expert at University of California, San Francisco.
And masks may protect the people wearing them by reducing the amount of droplets from others that might make contact with them.
In two U.S. food processing plants where masks were required and infection clusters occurred, Gandhi noted that most workers who developed COVID-19 had mild illness or no symptoms.
Research on a different coronavirus has also found low infection rates among people who frequently wore masks in public.
Experts say masks are particularly important with the new coronavirus because infected people can be contagious even if they don't have symptoms.
Does my employer have to say if a coworker has the virus?
Employers are generally not required to tell workers when someone in the workplace has tested positive for the coronavirus.
The U.S. Centers for Disease Control and Prevention recommends that companies monitor employees for symptoms and alert those who may have been in contact with an infected person. Some states may order businesses to follow such guidance.
Employers have the right to take employees' temperature and ask about symptoms or if they have been exposed to or diagnosed with the virus. If an employee doesn't respond to those questions, they can be barred from the workplace.
Businesses are required to provide a safe working environment. They also have to keep track of infections contracted on the job and report any hospitalizations or deaths related to the disease to the U.S. Occupational Safety and Health Administration.
Some workers are unsettled by the lack of information. Amazon, for example, alerted warehouse workers when someone tested positive for the virus, but didn't disclose a tally of how many workers tested positive. So workers began trying to keep track on their own.
There are also pending lawsuits against employers filed by workers who were exposed to or diagnosed with the coronavirus. In general, there's a high legal bar for finding an employer at fault for endangering employees and most claims are resolved via worker's compensation settlements. There has also been some debate over whether Congress should grant businesses liability protections during the pandemic.
What should I look for in a hand sanitizer?
Pick one that contains mostly alcohol, and has few other ingredients.
The U.S. Centers for Disease Control and Prevention says hand sanitizers should be at least 60% ethyl alcohol or 70% isopropyl alcohol. Other approved ingredients may include sterile distilled water, hydrogen peroxide and glycerin, according to the U.S. Food and Drug Administration.
You should avoid anything with methanol or 1-propanol, both of which can be highly toxic. The FDA also warns people to watch out for hand sanitizers packaged in food and drink containers, since accidentally ingesting them could be dangerous.
Health officials also say to avoid hand sanitizers that replace alcohol with benzalkonium chloride, which is less effective at killing certain bacteria and viruses. Making your own sanitizers isn't encouraged either; the wrong mix of chemicals can be ineffective or cause skin burns.
And you should only use hand sanitizer when you can't wash your hands with soap and water, says Barun Mathema, an infectious disease researcher at Columbia University. Hand washing is better at removing more germs.
Can I use a face shield instead of a mask?
No. Health officials don't recommend the clear plastic barriers as a substitute for masks because of the lack of research on whether they keep an infected person from spreading viral droplets to others.
However, those who want extra protection may want to wear a face shield in addition to a mask.
Face shields have the added benefit of protecting your eyes and discouraging you from touching your face by acting as a physical barrier, says Christopher Sulmonte, project administrator of the biocontainment unit at Johns Hopkins Hospital.
Meanwhile, the available research so far indicates that the best face shields for preventing viral spread are hooded or wrap around the sides and bottom of the face, according to the U.S. Centers for Disease Control and Prevention. That's because those shields leave less space for droplets from sneezing, coughing and talking to escape.
If you do wear a reusable face shield in addition to a mask, the CDC notes the importance of cleaning it after each use. The agency also says you should wash your hands before and after taking it off, and avoid touching your face while removing it.
What are the 3 types of coronavirus tests?
There are three broad categories of coronavirus tests in the U.S. Two diagnose whether you have an active infection, and a third indicates if you previously had the virus.
Here's how they work:
Most tests look for bits of the virus' genetic material, and require a nasal swab that is taken by a health professional and then sent to a lab. This is considered the most accurate way to diagnose an infection, but it's not perfect: The swab has to get a good enough sample so any virus can be detected.
These tests usually take hours to process at the lab so you likely won't get results back for at least a day, though a handful of rapid tests take about 15 minutes on site. Other genetic tests use saliva, instead of a swab.
A newer type of test looks for proteins found on the surface of the coronavirus, rather than the virus itself. These antigen tests are just hitting the market, and experts hope they'll help expand testing and speed up results.
Antigen tests aren't as accurate as genetic tests, but are cheaper, faster and require less specialized laboratory equipment. They still require a nasal swab by a health professional.
A recently approved test from Abbott Laboratories takes 15 minutes and can be performed at schools, offices and other locations.
Antibody tests look for proteins that the body makes to fight off infections in a patient's blood sample. Antibodies are a sign that a person previously had COVID-19.
Scientists don't yet know if antibodies protect people from another infection, or how long that protection might last. So antibody tests are mostly useful for researchers measuring what portion of the population was infected.
What are the rules on masks in schools?
Whether students have to wear masks, and the trouble they could face if they don't, depends on where they go to school.
The U.S. Centers for Disease Control and Prevention encourages masks for most students, especially when they are less than 6 feet apart. The exceptions are children younger than 2 and those with breathing problems or who can't remove the mask without help.
But how states and districts interpret the guidance varies. Ohio mandates masks across the board in K-12 schools. Massachusetts requires masks for students in second grade and higher, and encourages them for younger children. South Carolina says students have to wear masks in the hallways, but can take them off in the classroom if a teacher allows it.
Rules vary outside the United States, too. In Germany, Berlin requires masks in hallways, but not during classroom instruction. In the western state of North Rhine-Westphalia, masks are required in class as well. In the northern Italian town of Codogno that was hit hard by the virus, elementary and middle school students have to wear masks. They can be lowered during lessons, unless students can't maintain distance.
The issue has led to some contention. Back in the U.S., Utah's school mask mandate has drawn protest from parents, as well as support from some students who say it's worth it to be able to attend school in-person. The state also allows for some of the strictest consequences. Students and staff who refuse to follow the rules could be charged with a misdemeanor.
In New York City, officials say students will simply be sent home and told to attend school remotely if they refuse to wear masks.
How can I tell the difference between the flu and COVID-19?
It's impossible to tell without a test. Influenza and COVID-19 have such similar symptoms, you may need to get tested to know what's making you miserable.
Body aches, sore throat, fever, cough, shortness of breath, fatigue and headaches are symptoms shared by the two.
One difference? People with the flu typically feel sickest during the first week of illness. With COVID-19, people may feel the worst during the second or third week, and they may be sicker for a longer period.
Another difference: COVID-19 is more likely than the flu to cause a loss of taste or smell. But not everyone experiences that symptom, so it's not a reliable way to tell the viruses apart.
That leaves testing, which will become more important as flu season ramps up this fall in the Northern Hemisphere. Doctors will need to know test results to determine the best treatment.
It's also possible to be infected with both viruses at the same time, said Dr. Daniel Solomon, an infectious diseases expert at Brigham and Women's Hospital and Harvard Medical School in Boston.
Whether you get tested for one or both viruses may depend on how available tests are and which viruses are circulating where you live, he said.
"Right now we are not seeing community transmission of influenza, so widespread testing for the flu is not yet recommended," Solomon said.
Both the flu and coronavirus spread through droplets from the nose and mouth. Both can spread before people know they are sick. The flu has a shorter incubation period — meaning after infection it can take one to four days to feel sick — compared to the coronavirus, which can take two to 14 days from infection to symptoms.
On average, COVID-19 is more contagious than flu. But many people with COVID-19 don't spread the virus to anyone, while a few people spread it to many others. These "superspreader events" are more common with COVID-19 than flu, Solomon said.
Preventing the flu starts with an annual flu shot tailored to the strains of the flu virus that are circulating. Health officials would like to see record numbers of people get flu shots this year so hospitals aren't overwhelmed with two epidemics at once.
There's no vaccine yet for COVID-19, although several candidates are in the final testing stages.
Precautions against COVID-19 — masks, social distancing, hand-washing — also slow the spread of the flu, so health officials hope continued vigilance could lessen the severity of this year's flu season.
How easily does coronavirus spread among children?
It appears the virus can spread among children and teens, but how easily may vary by age. Research is still underway, but children under age 10 seem to be less likely than older kids to transmit the virus to other children and adults.
Children generally don't appear to get sick or experience symptoms as often as adults when they're infected. Some evidence suggests that may be particularly true for younger kids. That might help explain why they appear less likely to spread the virus — they're less likely to be coughing and sneezing.
Some of the latest evidence comes from a recent report that showed infected children in Utah day care centers and day camps spread the virus to family members, including siblings. That suggested very young children with no symptoms or very mild ones can spread infection, but that the rate of spread was low.
A large study from South Korea suggested that kids aged 10 and up may spread the virus more easily to family members than younger kids, and might even spread it as easily as adults.
Spread among children was also suspected in an outbreak at a Georgia summer camp.
With other respiratory viruses, "young children are the germ factories. In this case, it's different and we don't really know why,'' said Dr. Sean O'Leary of the American Academy of Pediatrics.
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